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Workshop: Asynchronous dynamics of logical models: assessing biologically relevant properties

Asynchronous dynamics of logical models: assessing biologically relevant properties

I2M Marseille November 3-4 2016


Elisabeth Remy, Claudine Chaouiya


As the logical modelling framework is increasingly used to tackle regulatory and signalling networks involved in e.g. human diseases, appropriate methods to make good use of these models are required. This workshop aims at gathering researchers (mathematicians, computer scientists and biologists) to discuss dynamical properties of these complex, discrete dynamics: how they relate to properties of the biological processes under study, what are the current methods and remaining needs to uncover such properties. In particular, topics to be discussed will relate to over/under-approximations of asynchronous dynamics, reachability analysis, identification of attractors and their basins of attraction.


Thursday, November 3, 2016,

9:45-10:00 Elisabeth Remy I2M Aix-Marseille University Introductory remarks
10:00-10:30 Madalena Chaves INRIA Sophia Antipolis Dissecting Boolean dynamics: synchronous vs. asynchronous module interconnections
11:00-11:30 Heike Siebert & Hannes Klarner Freie Universität Berlin Some open questions about boolean networks
11:30-12:00 Claudine Chaouiya Instituto Gulbenkian de Ciência, Portugal Reversing Boolean models
12:00-14:00 LUNCH
14:00-14:30 Elisabeth Remy I2M Aix-Marseille University Synchronous and asynchronous Boolean dynamics of circuits and chorded-circuits
14:30-15:00 Pedro Monteiro Instituto Superior Técnico Lisbon, Portugal On the number and structure of Boolean functions compatible with a regulatory network topology
15:00-15:30 Laurence Calzone Institut Curie, Paris News of MaBoSS: updates and population dynamics
15:30-16:00 COFFEE BREAK
16:00-16:30 Laurent Tournier INRA, Université Paris-Saclay, Jouy-en-Josas Inference of qualitative rules governing bacterial metabolic configurations under optimal resource allocation
16:30-17:00 TBA
17:00-18:00 round table, definition of the working groups for next day
20:00 DINNER

Friday, November 4 2016

9:00-10:45 Working groups
10:45-11:00 COFFEE BREAK
11:00-12:00 Working groups
12:00-13:30 LUNCH
13:30-15:00 presentations of the working groups
15:00-15:30 COFFEE BREAK
15:30-16:30 wrapping-up, conclusions and prospects


Laurence Calzone
Claudine Chaouiya
Madalena Chaves
Hannes Klarner
Pedro Monteiro
Brigitte Mossé
Aurélien Naldi
Elisabeth Remy
Heike Siebert
Denis Thieffry
Laurent Tournier